1. Studies on optimization of dose distribution

    The theme of our many years of therapy department of radiology, the pursuit of optimum dose distribution in time and space. Professor Wakabayashi first, based on biochemical studies of indirect effects, the optimal time and space (four dimensions) in order to achieve a dose distribution in intracavitary radiation therapy, and then filling in the world to remote high dose rate intracavitary irradiation the first commercial, if a small volume, split levels (units per dose) can be found to be in treatment, intracavitary irradiation was possible extraneous. 30 years later, the same treatment has become a worldwide standard.The pursuit of optimal temporal and spatial dose distribution, the second generation attempts at teaching bays external beam photon, a prospective study conducted in the 1970s for small short-term fractionated radiotherapy, made ​​the announcement. A high amount of one wire leads to a higher incidence of late effects spinal cord at doses the same total, fractionated radiotherapy at least short term, only available for small irradiation volume, vital organs such as the spinal cord is a precision showed that it is important to reduce the radiation dose as much as possible with a fixed law. In all they contain, such as pelvic organ irradiation Nouchi important, increasing the amount can not be shown in one line. Based on this, fixtures on the head and neck radiotherapy (shells) were first commercialized in Japan for use in all cases.

    In the 1980s, has spread the image CT · MRI, and is available early for radiotherapy with high precision, which on the basis of experience, and radiotherapy in 1987 in collaboration with Kyoto University from Associate Professor Tsujii CT system was developed for the plan. Currently, using a device similar to a treatment facility for almost all developed countries.

    The Hokkaido University School of Medicine contributed to the most recent radiation therapy field, which cerebral stereotactic radiotherapy has evolved since the early 1990s. Same treatment, in a small volume, small split in a way that irradiation using high precision locking device, located on the extension of the Research Professor Wakabayashi above creek. Is mainly clay and an assistant professor since 1993, has developed a brain stereotactic irradiation dose unit. On that basis, cerebral arteriovenous malformations, metastatic brain tumors with gamma knife similar, fractionation by adding acoustic schwannoma in spinal arteriovenous malformation, more like the outcome, and patients gathered from across the country The. Respect for fractionated stereotactic radiotherapy linear accelerator is also visitors from abroad, has been quoted in many papers research paper textbooks.

    The trunk is about the disease, unlike the brain, it is necessary to control the movement in the cardiac effects of intestinal peristalsis breathing, I knew it must be synchronized with the movement of the tumor treatment. In 1999, an associate professor from the clay, the company developed in collaboration with the motion tracking system irradiation, while confirming the three-dimensional location of tumor lesions per 0.03 seconds, the moment came to be irradiated as planned this position was possible. Rated the same treatment at home and abroad, has attracted attention.

  2. Radiobiological study

    The initial opening of the classroom studies, the indirect effect of radiation research, to pursue a number of inexplicable phenomena caused by radiation, incorporating the development of cell biology, has been developed. 1970 and transplanted tumors in animals makes it possible to examine the effect of radiation on it, just the reaction of cells to ecosystems Rubeku know, have studied the immunological effects of exposure to systemic .Miyamoto is a small dose total body irradiation assistant in the 1980s showed that tumor growth delay effect.

    In the 1990s, became the theme for our school that has not been applied to understanding radiation biology molecular biological techniques so far. Hashimoto is a graduate student small dose total body irradiation, by inducing a cellular immune control of numerous factors, showed that the potential to reduce metastasis. Healed of cancer after radiation, why are you living back to its original form. For example, a “tumor of the nose is healed then returns to the shape of the nose.” Seeking behavior of this group clay assistant professor, graduate students Omatsu, the fundamental mechanisms that are involved found that the HOX gene involved in morphogenesis. Higher research students to study the effects of radiation on the heart, and molecular biological study on the effects of fine capillaries.

    To examine the radiosensitivity of tumor cells has an important role to optimize radiation therapy. Nishioka et al assistant, and molecular biological techniques applied to tumor cells, pursuing the relationship between radiosensitivity and apoptosis. Tsuchiya graduate students to study the role of the p53 tumor suppressor gene in brain tumors, apoptosis in the brain are thin Glioblastoma relationship with radiosensitivity, suggesting that strongly involved in the irreversible arrest stage G0.

  3. Digitization of information

    Treatment of electronic patient information is that the world began prior to 1970, Professor Irie. Its philosophy is carried over to now, 30 years from 1970, what the treatment of patients with radiation therapy, treatment results, stored in a database such as survival, patient survival has helped in the analysis.From 1980, all electronic storage is now the image of the patient information is now being stored electronically matched photo management CT / MRI / treatment plan for all patients were treated in the hospital. This made ​​it possible to determine the best dose, including the activity of the tumor as well as forms for the various images.

    Furthermore, research assistant professor in 1998, Professor Miyasaka clay, have been using images digitized information consultation to other hospital patients treated with radiation. Three domestic locations will enable radiation treatment planning in one location and distance of South Korea, the emergency radiation treatment, 90% of patients able to walk and spinal paralysis that could become bedridden, has attracted the attention of the world. In addition, in order to simplify the work of the ward nurses, nursing support system was developed. It is through trial and error since the 1980s, in 1997 in conjunction with the hospital information system, is attracting attention from abroad as the most successful examples, from 1998 developed into a full hospital-wide nursing system.

  4. Using functional imaging in radiation treatment planning to

    K. Nishioka et al, with the cooperation of nuclear medicine courses from Dr. Eriko Tsukamoto, FDG in head and neck tumors? And conducting research in radiation treatment planning for the PET, has gained a high reputation in international conferences. Aoyama et al, with the cooperation of Dr. Kyosuke Kamata from neurosurgery, radiation treatment planning have been using magnetoencephalography and functional MRI images. They should have shown the direction of future development of radiation therapy, becoming a leading data presented at the Academy with a focus on U.S. domestic and international.