2020
学術論文
【治療部門】
Morita R, Abo D, Sakuhara Y, Soyama T, Katoh N, Miyamoto N, Uchinami Y, Shimizu S, Shirato H,
Kudo K. Percutaneous insertion of hepatic fiducial true-spherical markers for real-time adaptive radiotherapy. Minim Invasive Ther Allied Technol.
2020 Dec;29(6):334-343.doi: 10.1080/13645706.2019.1663217. Epub 2019 Sep 13.
Minatogawa H, Yasuda K, Dekura Y, Takao S, Matsuura T, Yoshimura T, Suzuki R, Yokota I, Fujima N, Onimaru R, Shimizu S, Aoyama H, Shirato H. Potential benefits of adaptive intensity-modulated proton therapy in nasopharyngeal carcinomas.
J Appl Clin Med Phys. 2021 Jan;22(1):174-183.doi: 10.1002/acm2.13128. Epub 2020 Dec 18.
Yasuda K, Minatogawa H, Dekura Y, Takao S, Tamura M, Tsushima N, Suzuki T, Kano S,Mizumachi T, Mori T, Nishioka K, Shido M, Katoh N, Taguchi H, Fujima N, Onimaru R,Yokota I, Kobashi K, Shimizu S, Homma A, Shirato H, Aoyama H. Analysis of acute-phase toxicities of intensity-modulated proton therapy using a model-based approach in pharyngeal cancer patients.
JRadiatRes.2021Mar10;62(2):329-337.doi: 10.1093/jrr/rraa130.
Prayongrat A, Srimaneekarn N, Sriswasdi S, Ito YM, Katoh N, Tamura M, Dekura Y, Toramatsu C, Khorprasert C, Amornwichet N, Alisanant P, Hirata Y, Hayter A, Shirato H, Shimizu S, Kobashi K. Assessment of the confidence interval in the multivariable normal tissue complication probability model for predicting radiation-induced liver disease in primary liver cancer.
J Radiat Res. 2021 May 12;62(3):483-493. doi: 10.1093/jrr/rrab011.
【医学物理】
Hirayama S, Matsuura T, Yasuda K, Takao S, Fujii T, Miyamoto N, Umegaki K, Shimizu S.
Difference in LET-based biological doses between IMPT optimization techniques: Robust and PTV-based optimizations.
J Appl Clin Med Phys. 2020 Apr;21(4):42-50.doi:10.1002/acm2.12844. Epub 2020 Mar 9.
Miyamoto N, Yokokawa K, Takao S, Matsuura T, Tanaka S, Shimizu S, Shirato H, Umegaki K.
Dynamic gating window technique for the reduction of dosimetric error in respiratory-gated spot-scanning particle therapy: An initial phantom study using patient tumor trajectory data.
J Appl Clin Med Phys. 2020 Apr;21(4):13-21. doi: 10.1002/acm2.12832. Epub 2020 Feb 18.
PMID: 32068347
Kasamatsu K, Matsuura T, Tanaka S, Takao S, Miyamoto N, Nam JM, Shirato H, Shimizu S, Umegaki K. The impact of dose delivery time on biological effectiveness in proton irradiation with various biological parameters. Med Phys. 2020 Sep;47(9):4644-4655. doi: 10.1002/mp.14381. Epub 2020 Aug 2.
Nomura Y, Wang J, Shirato H, Shimizu S, Xing L. Fast spot-scanning proton dose calculation method with uncertainty quantification using a three-dimensional convolutional neural network.
Phys Med Biol. 2020 Oct 26;65(21):215007. doi: 10.1088/1361-6560/aba164.
Nishio T, Nakamura M, Okamoto H, Kito S, Minemura T, Ozawa S, Kumazaki Y, Ishikawa M,
Tohyama N, Kurooka M, Nakashima T, Shimizu H, Suzuki R, Ishikura S, Nishimura Y.
An overview of the medical-physics-related verification system for radiotherapy multicenter
clinical trials by the Medical Physics Working Group in the Japan Clinical Oncology Group-
Radiation Therapy Study Group. J Radiat Res. 2020 Nov 16;61(6):999-1008. doi: 10.1093/jrr/rraa089.
Yoshimura T, Shimizu S, Hashimoto T, Nishioka K, Katoh N, Taguchi H, Yasuda K, Matsuura T, Takao S, Tamura M, Tanaka S, Ito YM, Matsuo Y, Tamura H, Horita K, Umegaki K, Shirato H.
Quantitative analysis of treatments using real-time image gated spot-scanning with synchrotron-based proton beam therapy system log data.
J Appl Clin Med Phys. 2020 Dec;21(12):10-19. doi: 10.1002/acm2.13029. Epub 2020 Nov 5.
Nakajima K, Hamada K, Ito R, Yoshida Y, Sutherland K, Ishikawa M, Ozaki M, Shirato H,
Hamada T. Stability of d-luciferin for bioluminescence to detect gene expression in freely moving mice for long durations. Luminescence.
2021 Feb;36(1):94-98. doi: 10.1002/bio.3917. Epub 2020 Aug 8.
Nomura Y, Tanaka S, Wang J, Shirato H, Shimizu S, Xing L. Calibrated uncertainty estimation for interpretable proton computed tomography image correction using Bayesian deep learning.
Phys Med Biol. 2021 Mar 16;66(6):065029. doi: 10.1088/1361-6560/abe956.
Nomura Y, Xu Q, Peng H, Takao S, Shimizu S, Xing L, Shirato H. Modified Fast Adaptive Scatter Kernel Superposition(mfASKS) Correction And Its Dosimetric Impact On CBCT-Based Proton Therapy Dose Calculation.Medical Physics. 47(1), January 2020
【放射線生物】
Nishioka S, Wu PH, Yakabe T, Giaccia AJ, Le QT, Aoyama H, Shimizu S, Shirato H, Onodera Y, Nam JM. Rab27b contributes to radioresistance and exerts a paracrine effect via epiregulin in glioblastoma. Neurooncol Adv.2020 Aug 8;2(1):vdaa091. eCollection Jan-Dec 2020.
Wu PH, Onodera Y, Giaccia AJ, Le QT, Shimizu S, Shirato H, Nam JM. Lysosomal trafficking mediated by Arl8b and BORC promotes invasion of cancer cells that survive radiation. Commun Biol. 2020 Oct 27;3(1):620. doi: 10.1038/s42003-020-01339-9.
共同研究・その他
Shimizu Y, Kudo K, Kameda H, Harada T, Fujima N, Toyonaga T, Tha KK, Shirato H. Prediction of Hypoxia in Brain Tumors Using a Multivariate Model Built from MR Imaging and 18F-Fluorodeoxyglucose Accumulation Data.
Magn Reson Med Sci. 2020 Aug 3;19(3):227-234. doi: 10.2463/mrms.mp.2019-0049. Epub 2019 Oct 15.
Miyata H, Osawa T, Abe T, Kikuchi H, Matsumoto R, Maruyama S, Nishioka K, Shimizu S, Hashimoto T, Shirato H, Shinohara N. The updated outcomes of bladder-preserving trimodal therapy using a real-time tumor-tracking radiotherapy system for patients with muscle-invasive bladder cancer.
Jpn J Clin Oncol. 2020 May 5;50(5):609-616.
Takizawa T, Tanabe S, Utsunomiya S, Nakano H, Yamada T, Sakai H, Ohta A, Saito H, Nakano T, Abe E, Kaidu M, Aoyama H. Dosimetric comparison of analytic anisotropic algorithm and Acuros XB algorithm in VMAT plans for high-grade glioma. Phys Med. 2020 May;73:73-82.
Sperduto PW, Mesko S, Li J, Cagney D, Aizer A, Lin NU, Nesbit E, Kruser TJ, Chan J, Braunstein S, Lee J, Kirkpatrick JP, Breen W, Brown PD, Shi D, Shih HA, Soliman H, Sahgal A, Shanley R, Sperduto W, Lou E, Everett A, Boggs DH, Masucci L, Roberge D, Remick J, Plichta K, Buatti JM, Jain S, Gaspar LE, Wu CC, Wang TJC, Bryant J, Chuong M, Yu J, Chiang V, Nakano T, Aoyama H, Mehta MP. Beyond an Updated Graded Prognostic Assessment (Breast GPA): A Prognostic Index and Trends in Treatment and Survival in Breast Cancer Brain Metastases From 1985 to Today. Int J Radiat Oncol Biol Phys.
2020 Jun 1;107(2):334-343.
Ogawa M, Tsuchiya A, Watanabe T, Setsu T, Kimura N, Matsuda M, Hoshiyama Y, Saito H, Kanazawa T, Shiotani M, Sato T, Yagi T, Igarashi K, Yoshimura N, Takamura M, Aoyama H, Terai S. Screening and follow-up of chronic liver diseases with understanding their etiology in clinics and hospitals.
JGH Open. 2020 Aug 24;4(5):827-837.
Sperduto PW, Mesko S, Li J, Cagney D, Aizer A, Lin NU, Nesbit E, Kruser TJ, Chan J, Braunstein S, Lee J, Kirkpatrick JP, Breen W, Brown PD, Shi D, Shih HA, Soliman H, Sahgal A, Shanley R, Sperduto W, Lou E, Everett A, Boggs DH, Masucci L, Roberge D, Remick J, Plichta K, Buatti JM, Jain S, Gaspar LE, Wu CC, Wang TJC, Bryant J, Chuong M, Yu J, Chiang V, Nakano T, Aoyama H, Mehta MP. Estrogen/progesterone receptor and HER2 discordance between primary tumor and brain metastases in breast cancer and its effect on treatment and survival. Neuro Oncol.2020 Sep 29;22(9):1359-1367.
Kasahara T, Ishizaki F, Kazama A, Yuki E, Yamana K, Maruyama R, Oshikane T, Kaidu M, Aoyama H, Bilim V, Nishiyama T, Tomita Y. High-dose-rate brachytherapy and hypofractionated external beam radiotherapy combined with long-term androgen deprivation therapy for very high-risk prostate cancer. Int J Urol. 2020 Sep;27(9):800-806.
Yokota T, Homma A, Kiyota N, Tahara M, Hanai N, Asakage T, Matsuura K, Ogawa T, Saito Y, Sano D, Kodaira T, Motegi A, Yasuda K, Takahashi S, Tanaka K, Onoe T, Okano S, Imamura Y, Ariizumi Y, Hayashi R. Immunotherapy for squamous cell carcinoma of the head and neck. Japan Clinical Oncology Group (JCOG) Head and Neck Cancer Study Group. Jpn J Clin Oncol.2020 Sep 28;50(10):1089-1096.
Nakano H, Tanabe S, Utsunomiya S, Yamada T, Sasamoto R, Nakano T, Saito H, Takizawa T, Sakai H, Ohta A, Abe E, Kaidu M, Aoyama H. Effect of setup error in the single-isocente technique on stereotactic radiosurgery for multiple brain metastases.J Appl Clin Med Phys. 2020 Dec;21(12):155-165.
Ohkoshi-Yamada M, Kamimura K, Shibata O, Morita S, Kaidu M, Nakano T, Maruyama K, Ota A, Saito H, Yamana N, Oshikane T, Goto Y, Yoshimura N, Tanabe S, Nakano H, Sakai M, Tanaka Y, Koseki Y, Arao Y, Abe H, Setsu T, Sakamaki A, Yokoo T, Kamimura H, Aoyama H, Terai S. Efficacy and Safety of the Radiotherapy for Liver Cancer: Assessment of Local Controllability and its Role in Multidisciplinary Therapy. Cancers (Basel).2020 Oct 13;12(10):2955.
Sperduto PW, Mesko S, Li J, Cagney D, Aizer A, Lin NU, Nesbit E, Kruser TJ, Chan J, Braunstein S, Lee J, Kirkpatrick JP, Breen W, Brown PD, Shi D, Shih HA, Soliman H, Sahgal A, Shanley R, Sperduto WA, Lou E, Everett A, Boggs DH, Masucci L, Roberge D, Remick J, Plichta K, Buatti JM, Jain S, Gaspar LE, Wu CC, Wang TJC, Bryant J, Chuong M, An Y, Chiang V, Nakano T, Aoyama H, Mehta MP. Survival in Patients With Brain Metastases: Summary Report on the Updated Diagnosis-Specific Graded Prognostic Assessment and Definition of the Eligibility Quotient. J Clin Oncol. 2020 Nov 10;38(32):3773-3784.
Okamoto M, Yamaguchi S, Ishi Y, Motegi H, Mori T, Hashimoto T, Terashita Y, Hirabayashi S,
Sugiyama M, Iguchi A, Cho Y, Manabe A, Houkin K. Diagnostic Capability of Cerebrospinal Fluid-Placental Alkaline Phosphatase Value in Intracranial Germ Cell Tumor. Oncology.2021 Jan;99(1):23-31.
Nakamaru Y, Suzuki M, Kano S, Mizumachi T, Tsushima N, Suzuki T, Honma A, Nakazono A, Kimura S, Onimaru R, Yasuda K, Shirato H, Homma A. The role of endoscopic resection for selected patients with sinonasal squamous cell carcinoma. Auris Nasus Larynx.2021 Feb;48(1):131-137.
Okano S, Homma A, Kiyota N, Tahara M, Hanai N, Asakage T, Matsuura K, Ogawa T, Saito Y, Sano D, Kodaira T, Motegi A, Yasuda K, Takahashi S, Tanaka K, Onoe T, Yokota T, Imamura Y, Ariizumi Y, Akimoto T, Hayashi R. Induction chemotherapy in locally advanced squamous cell carcinoma of the head and neck. Jpn J Clin Oncol.2021 Feb 8;51(2):173-179.
Oshikane T, Kaidu M, Abe E, Ohta A, Saito H, Nakano T, Honda M, Tanabe S, Utsunomiya S, Sasamoto R, Ishizaki F, Kasahara T, Nishiyama T, Tomita Y, Aoyama H, Ishikawa H. A comparative study of high-dose-rate brachytherapy boost combined with external beam radiation therapy versus external beam radiation therapy alone for high-risk prostate cancer. J Radiat Res.2021 Apr 5;rrab006.
Sakai M, Nakano H, Kawahara D, Tanabe S, Takizawa T, Narita A, Yamada T, Sakai H, Ueda M,
Sasamoto R, Kaidu M, Aoyama H, Ishikawa H, Utsunomiya S. Detecting MLC modeling errors using radiomics-based machine learning in patient-specific QA with an EPID for intensity-modulated radiation therapy. Med Phys.2021 Mar;48(3):991-1002.
Ohno T, Soejima T, Sekiguchi Y, Hashimoto T, Koike I, Matsubara H, Nakamura K, Nitta K, Takahashi S, Tsujino K, Wakatsuki M, Yoden E. JASTRO/JCS guidelines for radiotherapy in patients with cardiac implantable electronic devices. J Radiat Res.2021;62:172-84.
Kwon J, Rajamahendiran RM, Virani NA, Kunjachan S, Snay E, Harlacher M, Myronakis M, Shimizu S, Shirato H, Czernuszewicz TJ, Gessner R, Berbeco R. Use of 3-D Contrast-Enhanced Ultrasound to Evaluate Tumor Microvasculature After Nanoparticle-Mediated Modulation. Ultrasound Med Biol. 2020;46(2):369-376.
Xu Q, Wang J, Shirato H, Xing L. Region-specific Dictionary Learning-based Low-dose Thoracic CT Reconstruction, arXiv:2010.09953 [physics.med-ph] 2020
Hamada K, Oota A, Ito R, Kasahara S, Nakajima K, Kikuchi Y, Sutherland K, Ishikawa M, Shirato H,
Ozaki M, Hamada T. Double recording system of Period1 gene expression rhythm in the olfactory bulb and liver in freely moving mouse. Biochem Biophys Res Commun. 2020 Sep 3;529(4):898-903. doi: 10.1016/j.bbrc.2020.05.224. Epub 2020 Jul 29.
Sawamura D, Narita H, Hashimoto N, Nakagawa S, Hamaguchi H, Fujima N, Kudo K, Shirato H,
Tha KK. Microstructural Alterations in Bipolar and Major Depressive Disorders: A Diffusion Kurtosis Imaging Study. J Magn Reson Imaging. 2020 Oct;52(4):1187-1196. doi: 10.1002/jmri.27174. Epub 2020 Apr 23.
Ito R, Hamada K, Kasahara S, Kikuchi Y, Nakajima K, Sutherland K, Shirato H, Ozaki M, Ishikawa
M, Hamada T. Mouse period1 gene expression recording from olfactory bulb under free moving conditions with a portable optic fibre device. Luminescence. 2020 Dec;35(8):1248-1253. doi: 10.1002/bio.3884. Epub 2020 Jun 22.
Czerska K, Emert F, Kopec R, Langen K, McClelland JR, Meijers A, Miyamoto N, Riboldi M, Shimizu S, Terunuma T, Zou W, Knopf A, Rucinski A. Clinical practice vs. state-of-the-art research and future visions: Report on the 4D treatment planning workshop for particle therapy – Edition 2018 and 2019. Phys Med. 2021 Feb;82:54-63. doi: 10.1016/j.ejmp.2020.12.013. Epub 2021 Feb 13.
学会発表（国際学会）
American Society of Radiation Oncology (ASTRO) 62nd 2020 Annual Meeting, Miami/Online, 2020.10.25-28
Nishioka K, Nomura Y, Hashimoto T, Kinoshita R, Katoh N, Taguchi H, Yasuda K, Mori T, Uchinami
Y, Otsuka M, Matsuura T, Takao S, Suzuki R, Tanaka S, Yoshimura T, Aoyama H, Shimizu S: Automatic bladder delineation on MR images using a convolution neural network for online image-guided radiotherapy.
Nakano T, Aoyama H, Onodera S, Matsumo Y, Shimamoto S, Igaki H, Matsuo M, Oya N, Ohta A,
Saito H, Maruyama K, Kanemoto A, Sakurai T, Tanaka T, Kitamura N, Akazawa K, Maebayashi K
: Reduced-dose Whole Brain Radiation Therapy combined with Stereotactic Irradiation for solitary or oligo brain metastases aiming at minimizing deterioration of neurocognitive function without compromising intracranial tumor control: Preliminary Results.
The 2020 Joint AAPM | COMP Virtual Meeting
Nomura Y, Matsuura T, Shirato H, Shimizu S, Xing L. 2020 Deep Proton DoseNet: a deep neural network for proton dose distribution image super-resolution.
Nomura Y, Tanaka S, Wang J, Shirato H, Shimizu S and Xing L 2020 Uncertainty-aware reconstructed image correction for proton computed tomography using Bayesian deep learning.
ISMRM & SMRT VIRTUAL CONFERENCE & EXHIBITION
Tha KK, Sawamura D, Li X, Urushibata Y, Kudo K, Shirato H. Diffusion Imaging Correlates of Neurocognition in Healthy Adults: The Potentials of Sequences with Multiple Diffusion Encoding Schemes.
Tha KK, Katscher U, Kikuchi E, Kikuchi Y, Yoshino Y, Ishizaka K, Manabe N, Kudo K, Shirato H. Noninvasive Assessment of Electrical Conductivity of Lung and Mediastinal Mass Lesions: Feasibility and Potential Clinical Value
Takashi Mori, Shigeru Yamaguchi, Onimaru Rikiya, Takayuki Hashimoto, Hidefumi Aoyama
Two cases of re-irradiation for late recurrent or radiation-induced tumor after radiation therapy for pediatric brain tumors
Takayuki Hashimoto, Shigeru Yamaguchi, Takashi Mori, Akihiro Iguchi, Yukitomo Ishi,
Hiroaki Motegi, Rikiya Onimaru, Atsushi Manabe, Shinichi Shimizu and Hidefumi Aoyama: Proton Beam Therapy for Patients with Intracranial Ependymoma under 3 Years Old: Initial Clinical Outcomes
講演・セミナー・市民公開講座
（国際学会講演）
American Society of Radiation Oncology (ASTRO) 62nd 2020 Annual Meeting, Miami/Online, 2020.10.25-28
Hidefumi Aoyama, Vinai Gondi, Seema Nagpal, Eric A. Mellon. Controversies in Brain Metastasis Management: Interactive Case-Based Discussion. EDU 09: (SA-CME) (Educational Lecture)
KALC (Korean Association for Lung Cancer) International Conference Virtual. Korea/Web, 2020.11.20
Hidefumi Aoyama. Radiotherapeutic approach for patients with multiple brain metastases from NSCLC: Toward the optimal treatment selection. (Invited speaker)